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KMID : 0376219870240030393
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Chonnam Medical Journal
1987 Volume.24 No. 3 p.393 ~ p.398
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A Study on the cell volume regulation by the changes of plasma osmolality
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Abstract
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The authors have investigated cell volume regulation of red blood cell in rats when plasma osmolality changes. For this experiments, 20 Sprague-Dalwey rats were used and the mean corpuscular volume (MCV) of red cells was checked by Counter-Counter.
The following results were obtained.
1. Mean plasma sodium concentration of rats on day 1, 4, 5 and 8 in experiment were respectively 141.47±2.80mM, 108.15±4.64mM, 141.03±1.38mM and 140.84±0.93mM and the values on day 4 was significantly lowered compared with that on day 1 (P<0.001), and the value on days 5 significantly increased compared with that on day 4 (P<0.001).
2. Plasma osmolality on day 1, 4, 5 and 8 in experiment were respectively 287.74±4.06 mosmol/kg, 220.80±9.18 mosmol/kg, 286.42±2.26 mosmol/kg and 286.37±1.84 mosmol/kg, and the value on day 4 was significantly lowered compared with that on day 1 (P<0.001) and the value on day 5 was significantly increased compared with that on day 4 (P<0.001).
3. MCV of rats on day 1, 4, 5 and 8 in experiment were respectively 54.46± 0.73 fl, 54.68±0.66 fl, 54.61±0.76 fl and 54.57±0.77 fl and there was no significant difference of MCV on various experimental day in spite of marked changes of plasma osmolality. These experimental results show that volume regulation of red blood cell in rats functions completely when plasma osmolality changes and all in accordance with those already reported.
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